Complementary Cancer Treatment, Autoimmune Treatment, Alternative Cancer Therapy, Breast Cancer Treatment

2. Where is Avemar manufactured?

Avemar is manufactured by BiroPharma of Budapest, Hungary, under several quality assurance systems, including HACCP and GMP, and has been assessed and registered as meeting the ISO 9001:2000 standard and the standards for GMP production of pharmaceuticals by the National Institute of Pharmacy, Ministry of Health, Hungary. The manufacturing process is world patented so that anyone can use Avemar as a Complementary Cancer Treatment with Breast Cancer Treatment, Colon Cancer Treatment, leukaemia cancer treatment and Melanoma Cancer Treatment.

3. Who should take Avemar?

Avemar is recommended as a Colon Cancer Treatment, Melanoma Cancer Treatment, Lung Cancer Treatment, Breast Cancer Treatment, head and neck cancer treatment, oral cavity cancer treatment, pancreatic cancer treatment, Leukaemia Treatment and as a Complementary Cancer Treatment to clinical oncology treatment (surgery, radiotherapy, chemotherapy, immunotherapy). It is advised to use Avemar in any stages of cancer. Avemar is also recommended as an Autoimmune Treatment, in particular as a Rheumatoid Arthritis Treatment and treatment of SLE [Lupus].

Avemar would be sure to benefit anyone who has an immune deficiency, or who would like to prevent immune related diseases as Avemar acts as an Autoimmune Treatment.

4. What are the benefits of Avemar cancer treatment and Autoimmune Treatment?

Avemar is a truly remarkable natural compound that enhances the usefulness of commonly used conventional and Alternative Cancer Therapy choices. Research studies show daily use of Avemar supports mechanisms of cellular metabolism and immune function that maintain good health with particular benefit to people with autoimmune disease and many types of cancer.

In studies of animals and humans, use of Avemar prevented development of cancerous and pre-cancerous lesions (melanoma, pancreatic, colon and oral cancers, and others), reduced the incidence and number of metastatic cancers, improved quality of life by many measures and lengthened or even ceased the time to cancer progression following surgery, radiation and chemotherapy.

Cell line, animal and human studies looking at simultaneous use with many varieties of standard chemotherapy agents, showed that Avemar didn't interfere with any of the agents, but did enhance their effects, particularly with regard to tumour metastases. Avemar reduced the frequency and severity of many common side effects including nausea, fatigue, weight loss and immune suppression. Avemar also acted to Reduce side effects of chemotherapy, radiotherapy and other traditional cancer treatments.

In studies specifically looking at immune effects, Avemar was shown to speed the recovery of immune function following radiation and chemotherapy, inhibit immune suppression, improve Natural Killer (NK) cell recognition of target cells, act as an Immune Regulator and increase the invasive potential of white blood cells, helping them cross through blood vessel walls and into tumours.

Avemar is used widely as a Complementary Cancer Treatment during and after surgery, radiotherapy, chemotherapy and immune therapy. Results of human studies supported by research using rats, mice and also in-vitro studies, show that Avemar has been effective as a Colon Cancer Treatment, Melanoma Cancer Treatment, head and neck cancer treatment, oral cavity cancer treatment, Breast Cancer Treatment [including oestrogen-positive, oestrogen-negative and inflammatory], treatment for urological cancers, as well as a lymphoma cancer treatment, leukaemia cancer treatment, Lung Cancer Treatment and pancreatic cancer treatment.

AVEMAR has been proven to:

5. What research supports the use of Avemar cancer treatment and Autoimmune Treatment?

Abstracts of research on Avemar that demonstrate it's beneficial effects can be found on the US National Institutes of Health, National Library of Medicine website, www.pubmed.gov by using the search terms Avemar and "fermented wheat germ." Most of the Avemar published research is very technical, but worth reviewing.

Most of the publications are in peer-review journals, involving many groups of scientists, and showing a methodical progression from cell line (in vitro) and animal (in vivo) research to human clinical trials. Each piece of research listed concludes the effectiveness of Avemar as an alternative or Complementary Cancer Treatment and as an Autoimmune Treatment.

6. How does Avemar cancer treatment and Autoimmune Treatment work? [Mechanisms of Action]

Effects on the Immune System

Restoration of damaged immune response

Avemar has the ability to repair damaged immune systems and improve the functioning of the cellular immune response, an effect which is derived from it's stimulatory effect on the maturation and differentiation of bone marrow lymphocytes. Avemar's stimulatory effect on cellular immune response plays an important role in its clinical effectiveness.

Increase of blastic transformation:

"Our in vitro results show that Avemar pre-treatment of mice increases the blastic transformation inducing effect of Con A on peripheral T lymphocytes."

"From a therapeutic point of view, the immuno-stimulatory and immune function reconstructing effects, as well as blastic transformation enhancing potential of Avemar, may be exploited in various cases of immune response.

Effect of MSC on the immune response of mice.
Immunopharmacology 41: 183-186. 1999.
Scientific Paper - No 4. http://www.avemar.com/docs/4_IMMUNO.pdf

Effects on the metabolism of cancer cells

[a] Alters glucose/nucleic acid metabolism.

One of the most characteristic features of cancer cell biochemistry is the use of glucose, primarily for ribose synthesis, a key element of the nucleotides needed for DNA and RNA synthesis, whereas normal cells use glucose primarily for energy consumption processes. Avemar has a strong, specific and dose-dependent inhibitory effect on nucleotide/nucleic acid synthesis from glucose, forcing the cancer cells to use glucose for the synthesis of non-essential fatty acids and lipids just as normal cells do.

The key enzyme of ribose synthesis is transketolase. Avemar inhibits the activity of transketolase, thus decreasing or preventing the proliferation of cancer cells. As a result, the spread of malignant disease will be slowed or arrested and the performance status of patients taking Avemar will be improved.

Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells.

Pancreas 23: 141-147. 2001.
Scientific Paper - No 10 http://www.avemar.com/docs/10_PANCREAS.pdf

[b] Inhibits the synthesis of MHC-I (main histo-compatibility-I) molecules on the surface of tumour cells.

This protein acts as a disguise, making the tumour cells appear as normal. With the tumour cells 'unmasked', this leads to their destruction by the NK [Natural Killer] cells. The inhibition of MCH-I synthesis contributes to the increase of cellular immune response and the inhibition of cancer cell proliferation.

Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines.

Int J Oncol 20: 563-570. 2002.
Scientific Paper - No 26 http://www.avemar.com/docs/26_Int_J_Oncol.pdf

[c] Enhances TNF- Alpha (tumour necrosis factor alpha) production

TNF - Alpha is one of the major cytokines capable of killing tumour cells. By increasing it's production, tumour angiogenesis [growth of new blood vessels] is ameliorated and apoptosis [programmed cell death] of the cancer cells is directly stimulated.

[d] Increase in ICAM-1 level

The intracellular adhesion molecule ICAM-1 (CD54) ensures that immuno-competent cells can pass through vessel walls in order to approach cancer cells and kill them. Malignant tumours cannot grow beyond a diameter of 1 mm without developing their own vessel system (tumour angiogenesis). As newly developed tumour vessels contain a very low level of ICAM-I, immuno-competent cells do not invade the tumour via it's vessels. Avemar has a significant stimulatory effect on ICAM-1 protein synthesis, thus enhancing the cellular anti-cancer immune response. Avemar achieves this both directly and indirectly, by increasing the TNF - Alpha production of macrophages, which helps leukocytes and lymphocytes reach the tumour cells.

Synergistic Effect of Avemar on Proinflammatory Cytokine Production and Ras-Mediated Cell Activation. Ann. N.Y. Acad. Sci. 1051: 515-528. 2005.

Scientific Paper - No 43 http://www.avemar.com/docs/44_Telekes_et_al-NY.pdf

[e] Stimulation of apoptosis (programmed cell death) of tumour cells

Avemar's influence on apoptosis is one of the most important aspects of it's effect mechanism. The balance between apoptosis (programmed cell death) and cell proliferation is of primary importance in the histological integrity of tissues. A decreased ratio of apoptosis is a typical feature of malignant transformation. Avemar increases the apoptosis of tumour cells, resulting in their death, yet, at the same time, does not influence the life cycle of normal cells.

Cell cycle studies revealed an increased ratio of sub-G1/S phase cells at the detriment of S phase cells (an indirect marker of apoptosis); this was also demonstrated through FACS analysis (flow cytometry). Caspase-3 protease-mediated cleavage of PARP (poly-(ADP-ribose)polymerase), a process leading to apoptosis, is enhanced by the use of Avemar, something attributable to Avemar's impairment of DNA repair.

Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly (ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells.

J Biol Chem 277: 46408-46414. 2002
Scientific Paper - No 30 http://www.avemar.com/docs/30_JBC_REPRINT.pdf

[f] Inhibition of carcinogenesis

It was proven in an animal study that Avemar is capable of inhibiting the development of rat colon cancer.

Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats.

Carcinogenesis 22: 1649-1652. 2001
Scientific Paper - No 10 http://www.avemar.com/docs/15_CARCINOGENESIS.pdf

7. How do you take Avemar cancer treatment and Autoimmune Treatment?

Avemar comes in a powder form. It is available in a box of 30 sachets. One box of AVEMAR? weighs 510 g (30 x 17g per sachet). This is a one month supply.

Avemar, as a Complementary Cancer Treatment can be used alongside standard Breast Cancer Treatment, Colon Cancer Treatment, leukaemia cancer treatment, Melanoma Cancer Treatment and can also act as an Autoimmune Treatment.

Preparation of a single dose:

Dissolve by shaking in a container the contents of one sachet with 150 ml of cold water. Once the Avemar solution has been made, it should be consumed within 30 minutes. Any unused solution should be discarded.

Dosage:

For an adult of average weight (~70 kg), a single daily dose of 1 sachet (17g), prepared according to the above instructions, is recommended, ideally consumed approximately 1 hour before or after eating a meal, and two hours before or after any drugs or other dietary supplements.

Patients with a body weight of 90 kg [200lbs] or more should consume 2 sachets (34g) per day, ideally 1 hour before breakfast and 1 hour before dinner.

Avemar can also be prepared and consumed in soft drinks, non-carbonated mineral water, tea, cocoa or even soft yoghurt, providing that their vitamin C or ascorbic acid content is not significant. For those patients who are consuming vitamin C, allow 2 hours between the vitamin C preparation and the Avemar preparation.

For best results use Avemar daily.

Consult with a healthcare professional for recommended usage levels for children under 14 years of age, for guidance on alternative usage levels, and use in combination with other dietary supplements.

8. How should Avemar cancer treatment and Autoimmune Treatment be stored?

Each box of Avemar contains 30 individual sachets. There are 17g of product in each sachet. As some of Avemar's active ingredients are slightly heat sensitive, the final product must be kept in a refrigerator. The manufacturer recommends to store between 5 - 15 degrees C [ 39 - 59 degrees F]. No harm will come to the product should it be accidentally left at room temperature for a few days. However, exposure to temperatures above 30?C for even as few as 24 hours will damage Avemar.

9. When should Avemar cancer treatment and Autoimmune Treatment commence?

Ideally, treatment with Avemar should start right after the diagnosis is made and can be taken before any other active therapy [surgery, radiotherapy, chemotherapy] takes place. Avemar will work as an alternative or Complementary Cancer Treatment but can also help to Reduce side effects of chemotherapy and radiotherapy.

10. Are there any contra-indications using Avemar cancer treatment and Autoimmune Treatment?

Avemar should not be taken during pregnancy or nursing (breastfeeding). Avemar's use is prohibited for patients with organ or tissue transplant. The product cannot be used if the patient has bleeding gastrointestinal erosions (bleeding gastric or duodenal ulcer), enteritis/colitis (severe intestinal inflammation), malabsorption syndrome (severe absorption problem). Usage of the product is not advised in the presence of known gluten sensitivity (celiac sprue). Usage is also not advised in cases of hereditary fructose intolerance or if there is hypersensitivity to any product ingredient.

If undergoing a barium sulphate X-ray, Avemar use should be discontinued 2 days prior to the examination and reinstated 2 days after.
Diabetics may take Avemar under medical supervision taking into account the carbohydrate content of the product.

Allergen Statement: Avemar contains wheat ingredients.

Although the process of making the product removes all gluten, the principle allergen in wheat, the product comes in contact with gluten, and the possibility of contamination exists.

11. Are there any side effects from using Avemar Complementary Cancer Treatment and Autoimmune Treatment?

The vast majority of reports contain no data about substantial side effects. In rare instances, side effects, if they occur, are mild and transient, namely: diarrhoea, nausea, flatulence, soft stool, constipation, dizziness. Essentially, only very minor gastro-intestinal discomfort from Avemar use has been reported.

12. Are there any known interactions?

If Avemar is being taken as a Complementary Cancer Treatment and vitamin C is being administered, Avemar should be consumed at least 2 hours before or after the vitamin C. As Avemar may affect the absorption of other medications or supplements, Avemar should be taken at least 2 hours before or after taking the medication or supplement.

13. How long should someone take Avemar cancer treatment and Autoimmune Treatment?

People often report improvements in appetite, energy and daily activity within 3 weeks of beginning to take Avemar daily. Objective measures in terms of blood markers, CAT scans, MRI's etc, typically occur within 3 months.

For long-term results as a Complementary Cancer Treatment or complementary Autoimmune Treatment, one should use Avemar for at least 6 months.

Human clinical trials involving hundreds of subjects taking Avemar daily over a period of several years have proven it is safe and beneficial for long term use. Since Avemar supports the basic mechanisms that the body utilizes to respond to stress and the daily challenges to health, it may make sense to use it continuously.

14. Is there a recommendation for using Avemar Complementary Cancer Treatment and Autoimmune Treatment at a lower "maintenance level"?

Since research has shown very dramatic and unique benefits from using Avemar at the suggested level of use, and since this level of use is entirely safe and non-toxic, research has not considered the use of Avemar at lower levels. Consultation with a physician may help determine whether a lower "maintenance level" of Avemar use is appropriate.

15. Can Avemar cancer treatment and Autoimmune Treatment be used as a preventative?

Research in animals has shown that Avemar can reduce the rate of cancer initiation.

16. Is Avemar Alternative Cancer Treatment organic?

Avemar is 100% natural, made from wheat germ extract fermented by bakers yeast. It is not "certified organic," but it is free of chemicals and synthetics.

17. Can Avemar Complementary Cancer Treatment and Autoimmune Treatment be taken during radiotherapy or chemotherapy?

Extensive research, cell line, animal and human data, have shown that Avemar does not interfere with the mechanisms of most cancer therapies. In fact Avemar will Reduce side effects of chemotherapy and other cancer therapies whilst at the same time enhances their beneficial effects.

18. How does Avemar compare to other wheat germ supplements?

There is really no comparison. Pure wheat germ, wheat germ oil, and wheat germ extract powder (often found as an ingredient in "green drinks") may have generally beneficial properties, but research on these products has not shown the effects that Avemar has demonstrated on helping to maintain normal cellular metabolism and immune regulation. Go to research on Avemar for additional information.

19. Can Avemar Complementary Cancer Treatment be used with other dietary supplements?

There are many dietary supplements, and special diets that may benefit people who may wish to use Avemar. None of them will interfere with Avemar, and Avemar will not interfere with them, as long as other supplements are consumed two hours before, or two hours after taking Avemar. This is why Avemar is an ideal Complementary Cancer Treatment and Autoimmune Treatment. Consult with a health care professional that specializes in natural and nutritional medicine for a comprehensive protocol of diet, exercise and dietary supplements.

20. Can Avemar be used in conjunction with prescription medications?

Avemar has been subjected to hundreds of studies resulting in more than 30 peer reviewed publications, including studies that look at potential drug interactions. An answer as to whether Avemar will interact with a specific drug is best obtained by consulting with a pharmacist or physician.
Pharmacists and doctors can find research that can answer most questions on interactions by viewing the research pages.

21. What are the potential results of an overdose?

An overdose should have no consequences. The product , as an Alternative Cancer Treatment and Autoimmune Treatment has no toxic dose.

22. What is the story behind the name 'Avemar'?

The Hungarian, Dr Albert Szent-Györgyi, served in World War 1 from 1914 to 1916 as a Hungarian medic, where he observed firsthand the horrors associated with the use of mustard gas. After the war, he developed a keen interest in finding a cure for cancer when he learned mustard gas derivatives [pre-cursors to chemotherapy] were being used as a form of treatment. His work in the field of cancer intensified after losing both his daughter and wife to the disease.

Albert Szent-Györgyi, is probably best known for being awarded the 1937 Nobel Prize in Physiology and Medicine for his work on the roles played by certain organic compounds [especially vitamin C] in the oxidation of nutrients by cells. He is also noted for describing the process of cellular metabolism, known as the Szent-Györgyi/Krebs cycle (or just the Krebs cycle). As early as 1941, he was discussing the role of unpaired electrons (which we now refer to as free radicals), and their possible link to cancer, as well as the importance of certain protective enzymes and antioxidants, such as vitamin C, that can help prevent cancer.

He certainly had his share of critics, particularly when it came to his theories on cancer. After Györgyi emigrated to the US following World War II, his continuing work on cancer was based on his theory that certain naturally occurring compounds called quinones (along with similar compounds), could be instrumental in helping to control the proper metabolism in cells. As we now know, uncontrolled metabolism and rampant cell division is a defining characteristic of cancer. Györgyi noted that wheat germ is a potent source of these quinine compounds, and he suggested that they could be concentrated further through fermentation with baker's yeast. Györgyi's early research experiments were very promising.

His theories about specific quinines found in wheat germ, and their ability to inhibit cancer, appeared to be correct. Just as his work was gaining momentum, though, his concept of regulating metabolism to prevent or control cancer was overshadowed by the new 'war on cancer' and the belief at the time that cancer therapies should concentrate on killing cancer at any cost. As a result, Györgyi's work suffered from funding problems and was largely overlooked. [As a matter of principle, he refused to accept government funding and be bound to any restrictions on his research or its outcome.] He died in 1986, with his research unfinished.

In the early 1990's, the fall of communism in Eastern Europe opened the door for more freedom, particularly in the field of scientific research. This sudden scientific freedom allowed Dr. Máté Hidvégi, also of Hungary, to resume and build on Dr. Szent- Györgyi's initial work. And it was Dr. Hidvégi who actually developed the first fermented wheat germ extract for human consumption. Dr. Hidvégi's initial work was also limited by a lack of funding. At one point, his personal finances were completely exhausted and it appeared that the benefits of fermented wheat germ would fade into obscurity once again.

A highly devoted and dedicated catholic, Dr. Hidvégi prayed to Mary, Mother of God, to ask for guidance and help. The very next day he was approached by someone willing to provide the needed funding for his research. To show his thanks, Dr. Hidvégi named the extract Avemar, in honour of Ave Maria ["Hail Mary" in Latin].